Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort
Identifieur interne : 001056 ( Main/Exploration ); précédent : 001055; suivant : 001057Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort
Auteurs : Brit Mollenhauer [Allemagne] ; Ellen Trautmann [Allemagne] ; Friederike Sixel-Döring [Allemagne] ; Tamara Wicke [Allemagne] ; Jens Ebentheuer [Allemagne] ; Martina Schaumburg [Allemagne] ; Elisabeth Lang [Allemagne] ; Niels K. Focke [Allemagne] ; Kishore R. Kumar [Allemagne] ; Katja Lohmann [Allemagne] ; Christine Klein [Allemagne] ; Michael G. Schlossmacher [Canada] ; Ralf Kohnen [Allemagne] ; Tim Friede [Allemagne] ; Claudia Trenkwalder [Allemagne]Source :
- Neurology [ 0028-3878 ] ; 2013.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
Abstract
Objective: To determine nonmotor signs (NMS) and evaluate the utility of several diagnostic tools in patients with de novo Parkinson disease (PD). Methods: This is a large single-center study of the DeNoPa cohort, including frequency-matched healthy controls. This study covers motor signs, NMS, and a combination of diagnostic tests including olfactory testing, transcranial sonography of substantia nigra (TCS), and polysomnography (PSG). We report the frequency and characteristics of NMS and the outcomes of nonmotor tests at the time of diagnosis. Results: Cross-sectional analyses of baseline investigations identified significant differences in the NMS Questionnaire (NMSQuest) and the Scopa-AUT Gastrointestinal score in 159 drug-naïve PD patients vs 110 controls. In addition, patients with PD showed reduced olfactory function, hyperechogenicity on TCS, and higher frequency of REM sleep behavior disorder (RBD). In exploring predictive markers, we found that the combination of several investigations, i.e., the NMSQuest, Scopa-AUT Gastrointestinal score, and Smell Identification Test reached an area under the receiver operating characteristic curve (AUC) of 0.913 (95% confidence interval [CI] 0.878-0.948). With the addition of serum cholesterol and mean heart rate values, the AUC value reached 0.919 (95% CI 886-0.953); when TCS and PSG were added, the AUC increased to 0.963 (95% CI 0.943-0.982). Conclusions: We show feasibility and utility of standardized data acquisition in a large, single-center cohort of patients with de novo PD and matched healthy controls. The baseline results from our prospective investigations reached a value of >0.9 sensitivity and specificity for biological markers when we added routine laboratory investigations and quantified nonmotor features including sleep.
Affiliations:
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Focke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Kishore R" sort="Kumar, Kishore R" uniqKey="Kumar K" first="Kishore R." last="Kumar">Kishore R. 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Schlossmacher</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Program in Neuroscience Ottawa Hospital Research Institute; Division of Neurology, The Ottawa Hospital, University of Ottawa</s1><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Program in Neuroscience Ottawa Hospital Research Institute; Division of Neurology, The Ottawa Hospital, University of Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>ReSearch Pharmaceutical Services</s1><s2>Nuremberg</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Nuremberg</wicri:noRegion><wicri:noRegion>ReSearch Pharmaceutical Services</wicri:noRegion><wicri:noRegion>ReSearch Pharmaceutical Services</wicri:noRegion></affiliation></author><author><name sortKey="Friede, Tim" sort="Friede, Tim" uniqKey="Friede T" first="Tim" last="Friede">Tim Friede</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Medical Statistics, University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>University Medical Centre</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" 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type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000064</idno><idno type="wicri:doubleKey">0028-3878:2013:Mollenhauer B:nonmotor:and:diagnostic</idno><idno type="wicri:Area/Main/Merge">001071</idno><idno type="wicri:Area/Main/Curation">001056</idno><idno type="wicri:Area/Main/Exploration">001056</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Nonmotor and diagnostic findings in subjects with de novo Parkinson disease of the DeNoPa cohort</title><author><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Neuropathology, University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>1 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>University Medical Centre</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Trautmann, Ellen" sort="Trautmann, Ellen" uniqKey="Trautmann E" first="Ellen" last="Trautmann">Ellen Trautmann</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Psychology , University Kassel</s1><s3>DEU</s3><sZ>2 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University Kassel</wicri:noRegion><wicri:noRegion>Department of Psychology , University Kassel</wicri:noRegion></affiliation></author><author><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Wicke, Tamara" sort="Wicke, Tamara" uniqKey="Wicke T" first="Tamara" last="Wicke">Tamara Wicke</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Ebentheuer, Jens" sort="Ebentheuer, Jens" uniqKey="Ebentheuer J" first="Jens" last="Ebentheuer">Jens Ebentheuer</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Schaumburg, Martina" sort="Schaumburg, Martina" uniqKey="Schaumburg M" first="Martina" last="Schaumburg">Martina Schaumburg</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Lang, Elisabeth" sort="Lang, Elisabeth" uniqKey="Lang E" first="Elisabeth" last="Lang">Elisabeth Lang</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation></author><author><name sortKey="Focke, Niels K" sort="Focke, Niels K" uniqKey="Focke N" first="Niels K." last="Focke">Niels K. Focke</name><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion></affiliation></author><author><name sortKey="Kumar, Kishore R" sort="Kumar, Kishore R" uniqKey="Kumar K" first="Kishore R." last="Kumar">Kishore R. Kumar</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</s1><s3>DEU</s3><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>University of Luebeck</wicri:noRegion><wicri:noRegion>Section of Clinical and Molecular Neurogenetics at the Department of Neurology, University of Luebeck</wicri:noRegion></affiliation></author><author><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. Schlossmacher</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>Program in Neuroscience Ottawa Hospital Research Institute; Division of Neurology, The Ottawa Hospital, University of Ottawa</s1><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country><wicri:noRegion>Program in Neuroscience Ottawa Hospital Research Institute; Division of Neurology, The Ottawa Hospital, University of Ottawa</wicri:noRegion></affiliation></author><author><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>ReSearch Pharmaceutical Services</s1><s2>Nuremberg</s2><s3>DEU</s3><sZ>13 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Nuremberg</wicri:noRegion><wicri:noRegion>ReSearch Pharmaceutical Services</wicri:noRegion><wicri:noRegion>ReSearch Pharmaceutical Services</wicri:noRegion></affiliation></author><author><name sortKey="Friede, Tim" sort="Friede, Tim" uniqKey="Friede T" first="Tim" last="Friede">Tim Friede</name><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Department of Medical Statistics, University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>14 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>University Medical Centre</wicri:noRegion><wicri:noRegion>Goettingen</wicri:noRegion></affiliation></author><author><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Center of Parkinsonism and Movement Disorders, Paracelsus-Elena-Klinik</s1><s2>Kassel</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>7 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Kassel</region><settlement type="city">Cassel (Hesse)</settlement></placeName></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Department of Neurosurgery University Medical Centre</s1><s2>Goettingen</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Goettingen</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion><wicri:noRegion>Department of Neurosurgery University Medical Centre</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Neurology</title><title level="j" type="abbreviated">Neurology</title><idno type="ISSN">0028-3878</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>De novo</term><term>Diagnosis</term><term>Human</term><term>Nervous system diseases</term><term>Parkinson disease</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Maladie de Parkinson</term><term>Pathologie du système nerveux</term><term>Diagnostic</term><term>Homme</term><term>De novo</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Objective: To determine nonmotor signs (NMS) and evaluate the utility of several diagnostic tools in patients with de novo Parkinson disease (PD). Methods: This is a large single-center study of the DeNoPa cohort, including frequency-matched healthy controls. This study covers motor signs, NMS, and a combination of diagnostic tests including olfactory testing, transcranial sonography of substantia nigra (TCS), and polysomnography (PSG). We report the frequency and characteristics of NMS and the outcomes of nonmotor tests at the time of diagnosis. Results: Cross-sectional analyses of baseline investigations identified significant differences in the NMS Questionnaire (NMSQuest) and the Scopa-AUT Gastrointestinal score in 159 drug-naïve PD patients vs 110 controls. In addition, patients with PD showed reduced olfactory function, hyperechogenicity on TCS, and higher frequency of REM sleep behavior disorder (RBD). In exploring predictive markers, we found that the combination of several investigations, i.e., the NMSQuest, Scopa-AUT Gastrointestinal score, and Smell Identification Test reached an area under the receiver operating characteristic curve (AUC) of 0.913 (95% confidence interval [CI] 0.878-0.948). With the addition of serum cholesterol and mean heart rate values, the AUC value reached 0.919 (95% CI 886-0.953); when TCS and PSG were added, the AUC increased to 0.963 (95% CI 0.943-0.982). Conclusions: We show feasibility and utility of standardized data acquisition in a large, single-center cohort of patients with de novo PD and matched healthy controls. The baseline results from our prospective investigations reached a value of >0.9 sensitivity and specificity for biological markers when we added routine laboratory investigations and quantified nonmotor features including sleep.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Canada</li></country><region><li>District de Kassel</li><li>Hesse (Land)</li></region><settlement><li>Cassel (Hesse)</li></settlement></list><tree><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name></region><name sortKey="Ebentheuer, Jens" sort="Ebentheuer, Jens" uniqKey="Ebentheuer J" first="Jens" last="Ebentheuer">Jens Ebentheuer</name><name sortKey="Focke, Niels K" sort="Focke, Niels K" uniqKey="Focke N" first="Niels K." last="Focke">Niels K. Focke</name><name sortKey="Friede, Tim" sort="Friede, Tim" uniqKey="Friede T" first="Tim" last="Friede">Tim Friede</name><name sortKey="Klein, Christine" sort="Klein, Christine" uniqKey="Klein C" first="Christine" last="Klein">Christine Klein</name><name sortKey="Kohnen, Ralf" sort="Kohnen, Ralf" uniqKey="Kohnen R" first="Ralf" last="Kohnen">Ralf Kohnen</name><name sortKey="Kumar, Kishore R" sort="Kumar, Kishore R" uniqKey="Kumar K" first="Kishore R." last="Kumar">Kishore R. Kumar</name><name sortKey="Lang, Elisabeth" sort="Lang, Elisabeth" uniqKey="Lang E" first="Elisabeth" last="Lang">Elisabeth Lang</name><name sortKey="Lohmann, Katja" sort="Lohmann, Katja" uniqKey="Lohmann K" first="Katja" last="Lohmann">Katja Lohmann</name><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Mollenhauer, Brit" sort="Mollenhauer, Brit" uniqKey="Mollenhauer B" first="Brit" last="Mollenhauer">Brit Mollenhauer</name><name sortKey="Schaumburg, Martina" sort="Schaumburg, Martina" uniqKey="Schaumburg M" first="Martina" last="Schaumburg">Martina Schaumburg</name><name sortKey="Sixel Doring, Friederike" sort="Sixel Doring, Friederike" uniqKey="Sixel Doring F" first="Friederike" last="Sixel-Döring">Friederike Sixel-Döring</name><name sortKey="Trautmann, Ellen" sort="Trautmann, Ellen" uniqKey="Trautmann E" first="Ellen" last="Trautmann">Ellen Trautmann</name><name sortKey="Trautmann, Ellen" sort="Trautmann, Ellen" uniqKey="Trautmann E" first="Ellen" last="Trautmann">Ellen Trautmann</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><name sortKey="Trenkwalder, Claudia" sort="Trenkwalder, Claudia" uniqKey="Trenkwalder C" first="Claudia" last="Trenkwalder">Claudia Trenkwalder</name><name sortKey="Wicke, Tamara" sort="Wicke, Tamara" uniqKey="Wicke T" first="Tamara" last="Wicke">Tamara Wicke</name></country><country name="Canada"><noRegion><name sortKey="Schlossmacher, Michael G" sort="Schlossmacher, Michael G" uniqKey="Schlossmacher M" first="Michael G." last="Schlossmacher">Michael G. 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